S8939414
≥98%(HPLC),powder , 18172-33-3
Synonym(s):
CPA;Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1026.03 | In Stock |
|
| 10mg | RMB1784.15 | In Stock |
|
| 50mg | RMB6464.07 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 245-246°C |
| Boiling point: | 472.86°C (rough estimate) |
| Density | 1.2171 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | 4.50±1.00(Predicted) |
| color | white to off-white |
| Water Solubility | Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water. |
| InChI | 1S/C20H22N2O3/c1-10(23)15-18(24)17-12-9-21-14-7-5-6-11(16(12)14)8-13(17)20(2,3)22(4)19(15)25/h5-7,9,13,17,21,23H,8H2,1-4H3/b15-10- |
| InChIKey | WJCPGKDPOYBOOJ-GDNBJRDFSA-N |
| SMILES | CN1C(=O)C(=C(\C)O)\C(=O)C2C(Cc3cccc4[nH]cc2c34)C1(C)C |
| EPA Substance Registry System | Cyclopiazonic acid (18172-33-3) |
Description and Uses
Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
Cyclopiazonic acid from?Penicillium cyclopium has been used:
- as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
- as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
- as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
- as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+?during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P301+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UY8587000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29337900 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Oral |
| Hazardous Substances Data | 18172-33-3(Hazardous Substances Data) |
| Toxicity | chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl, |
