≥98%(HPLC),powder , 218137-86-1

Synonym(s):
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid;C 75;C-75

CAS NO.：218137-86-1

Empirical Formula: C14H22O4

Molecular Weight: 254.32

MDL number: MFCD03265452

PRODUCT Properties

• Boiling point: 432.1±45.0 °C(Predicted)
• Density: 1.08±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 18 mg/mL
• pka: 3.08±0.40(Predicted)
• form: solid
• color: off-white
• InChI: 1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
• InChIKey: VCWLZDVWHQVAJU-UHFFFAOYSA-N
• SMILES: CCCCCCCCC1OC(=O)C(=C)C1C(O)=O

Description and Uses

C75 has been used:

• as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
• as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
• as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• PPE: Eyeshields, Gloves, type N95 (US)
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids