S8955914
≥98%(HPLC) , 111358-88-4
Synonym(s):
KT-5555 hydrate;Lestaurtinib hydrate
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1592.53 | In Stock |
|
| 5mg | RMB6344.07 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 215-220°C |
| Boiling point: | 723.0±60.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | DMSO: >10mg/mL |
| form | white powder |
| pka | 13.37±0.40(Predicted) |
| color | White or off-white |
| Stability: | Photosensitive |
| InChIKey | LPOQWFBZBJTLEO-GMEYHWBASA-N |
| SMILES | O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35 |
Description and Uses
Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4Potent Trk inhibitor.5Cell permeable.
Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
