Sulindac Sulfide , >98.0%(HPLC) , 32004-67-4
Synonym(s):
(Z)-5-Fluoro-2-methyl-1-[ p-(methylthio)benzylidene]indene-3-acetic Acid;(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid;Sulindac Sulfide - CAS 32004-67-4 - Calbiochem
CAS NO.：32004-67-4
Empirical Formula: C20H17FO2S
Molecular Weight: 340.41
MDL number: MFCD00869764
EINECS: 250-892-2
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB1408.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 189-191°C |
| Boiling point: | 526.3±50.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| RTECS | NK8236000 |
| storage temp. | +15C to +30C |
| solubility | DMSO: >22 mg/mL |
| form | solid |
| pka | 4.26±0.10(Predicted) |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23) |
| InChIKey | LFWHFZJPXXOYNR-UHFFFAOYSA-N |
| SMILES | C1(=CC2=CC=C(SC)C=C2)C2=C(C=C(F)C=C2)C(CC(O)=O)=C1C |
| CAS DataBase Reference | 32004-67-4(CAS DataBase Reference) |
Description and Uses
Sulindac sulfide is an aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity. It has a role as a non-steroidal anti-inflammatory drug, an apoptosis inducer and an antineoplastic agent. It is an aryl sulfide, an organofluorine compound and a monocarboxylic acid. It derives from a sulindac.
Sulindac sulfide is an active metabolite of Sulindac that inhibits for COX. Sulindac is a non-steroidal anti-inflammatory drug. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP b.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H317-H334-H361 |
| Precautionary statements | P201-P280-P301+P312-P302+P352-P304+P340+P312-P308+P313 |
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Statements | 22-42/43-63 |
| WGK Germany | 3 |
| HS Code | 2930.90.2900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Repr. 2 Resp. Sens. 1 Skin Sens. 1 |
| REACH Registrations | Active |
