Cyclovirobuxine , Analysis standard , 860-79-7

CAS NO.：860-79-7

Empirical Formula: C26H46N2O

Molecular Weight: 402.66

MDL number: MFCD00468040

PRODUCT Properties

• Melting point: 220-221 °C (decomp)(Solv: acetone (67-64-1))
• Boiling point: 524.75°C (rough estimate)
• Density: 0.9815 (rough estimate)
• refractive index: 1.5300 (estimate)
• storage temp.: Store at -20°C
• solubility: Soluble to 20 mg/mL (49.66 mM) in Ethanol
• form: cryst.
• pka: 15.12±0.70(Predicted)
• color: White
• LogP: 4.635 (est)
• CAS DataBase Reference: 860-79-7(CAS DataBase Reference)

Description and Uses

A Buxus alkaloid of the steroidal class, this base has been found in the strong base fraction of the alkaloidal extract from Buxus microphylla Sieb. et Zucco var. suffruticosa and B. microphylla Sieb. et Zucco var. suffruticosa Makino forma major. It is dextrorotatory having a specific rotation of [α]²³_D + 98° (c 4.40,CHC13)and yields a series of salts and derivatives including the dihydrobromide, m.p. 288-292°C (dec.); dihydriodide, m.p. 276-8°C (dec.); diperchlorate, m.p. 244- 5°C (dec.); dioxalate as an amorphous powder, m.p. 264-7°C (dec.): the N:Ndiacetyl derivative, m.p. 278-281°C (dec.) with [α]²⁴_D + 10° (c 1.94, CHC13) and the O,N,N-triacetyl derivative, m.p. 246-8°C with [α]²⁴_D - 12° (c 2.40, CHCI3)·
The structure and stereochemistry of the base have been elucidated from chemical analysis, spectroscopic evidence and comparison with other alkaloids of this class.

Cyclovirobuxine D is a potential preventative agent of cardiac dysfunction.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501
• Safety Statements: 24/25
• HS Code: 29420000
• Toxicity: LD50 oral in mouse: 293mg/kg