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A6530912

Oridonin , Analysis of standard products, ≥98% , 28957-04-2

Synonym(s):
7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one;Isodonol;Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem

CAS NO.:28957-04-2

Empirical Formula: C20H28O6

Molecular Weight: 364.44

MDL number: MFCD00221762

Pack Size Price Stock Quantity
20MG RMB204.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 248-250°C
Boiling point: 599.8±50.0 °C(Predicted)
Density  1.42±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO: >20mg/mL
form  Yellow solid
pka 10.96±0.70(Predicted)
color  White or off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey SDHTXBWLVGWJFT-WNKSEERENA-N
SMILES O[C@@]12OC[C@]3([C@H](CCC(C)(C)[C@@]3([H])[C@@H]1O)O)[C@]1([H])CC[C@@]3([H])C(=C)C(=O)[C@@]21C3([H])O |&1:1,4,5,11,13,16,20,26,r|

Description and Uses

Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties. It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 μM, respectively). Oridonin inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells in a dose-dependent manner, halts the cell cycle at the G2/M phase, and induces apoptosis when used at a concentration of 20 μM. It decreases the expression of cleaved poly(ADP-ribose) polymerase (PARP), caspase-3, caspase-7, and Bims and the protein levels of phosphorylated AKT and reduces AKT activity. Oridonin reduces tumor growth in patient-derived mouse tumor models when administered at doses of 40 and 160 mg/kg. Oridonin is also an inhibitor of NLRP3 inflammasome assembly and activation. It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes when administered at a dose of 3 mg/kg.

Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  40
Safety Statements  36/37-24/25
WGK Germany  2
RTECS  NZ8177000
HS Code  29389090

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