Oridonin , 98% , 28957-04-2
Synonym(s):
7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one;Isodonol;Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB547.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 248-250°C |
| Boiling point: | 599.8±50.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >20mg/mL |
| form | Yellow solid |
| pka | 10.96±0.70(Predicted) |
| color | White or off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChIKey | SDHTXBWLVGWJFT-WNKSEERENA-N |
| SMILES | O[C@@]12OC[C@]3([C@H](CCC(C)(C)[C@@]3([H])[C@@H]1O)O)[C@]1([H])CC[C@@]3([H])C(=C)C(=O)[C@@]21C3([H])O |&1:1,4,5,11,13,16,20,26,r| |
Description and Uses
Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties. It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 μM, respectively). Oridonin inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells in a dose-dependent manner, halts the cell cycle at the G2/M phase, and induces apoptosis when used at a concentration of 20 μM. It decreases the expression of cleaved poly(ADP-ribose) polymerase (PARP), caspase-3, caspase-7, and Bims and the protein levels of phosphorylated AKT and reduces AKT activity. Oridonin reduces tumor growth in patient-derived mouse tumor models when administered at doses of 40 and 160 mg/kg. Oridonin is also an inhibitor of NLRP3 inflammasome assembly and activation. It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes when administered at a dose of 3 mg/kg.
Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 36/37-24/25 |
| WGK Germany | 2 |
| RTECS | NZ8177000 |
| HS Code | 29389090 |
