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A6955458

Carmustine , 10mMinDMSO , 154-93-8

Synonym(s):
1,3-Bis(2-chloroethyl)-1-nitrosourea;BCNU

CAS NO.:154-93-8

Empirical Formula: C5H9Cl2N3O2

Molecular Weight: 214.05

MDL number: MFCD00057706

EINECS: 205-838-2

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 30 °C (lit.)
Density  1.6948 (rough estimate)
refractive index  1.6100 (estimate)
storage temp.  -20°C
solubility  insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH
form  (Oily liquid to amorphous solid)
pka 10.19±0.46(Predicted)
color  Light-yellow powder
Water Solubility  <0.1 g/100 mL at 18 ºC
Merck  14,1845
Stability: Temperature Sensitive
InChIKey DLGOEMSEDOSKAD-UHFFFAOYSA-N

Description and Uses

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

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Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H350-H360
Precautionary statements  P201-P280-P301+P330+P331+P310-P308+P313
Hazard Codes  T+
Risk Statements  45-46-60-61-28
Safety Statements  53-22-36/37/39-45
RIDADR  3249
WGK Germany  3
RTECS  YS2625000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29241990
Toxicity LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson)

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