ALLN , 10mMinDMSO , 110044-82-1

Synonym(s):
ALLN - CAS 110044-82-1 - Calbiochem;Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V;InSolution ALLN - CAS 110044-82-1 - Calbiochem;LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V

CAS NO.：110044-82-1

Empirical Formula: C20H37N3O4

Molecular Weight: 383.53

MDL number: MFCD00065505

EINECS: 999-999-2

PRODUCT Properties

• Melting point: 182 °C
• Boiling point: 510.42°C (rough estimate)
• Density: 1.1322 (rough estimate)
• refractive index: 1.6300 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: soluble
• form: powder
• pka: 13.53±0.46(Predicted)
• color: white
• biological source: synthetic (organic)
• Water Solubility: Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
• BRN: 7656053
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Description and Uses

ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1?Inhibits cell cycle progression at G1/S?and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2?Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3?Blocks AIF-mediated necroptosis.4?Cell permeable.

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P271-P280
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10
• HS Code: 29241900