1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine , 95% , 1228780-72-0

CAS NO.：1228780-72-0

Empirical Formula: C19H27ClN2

Molecular Weight: 318.88

MDL number: MFCD28129720

PRODUCT Properties

• Boiling point: 421.2±45.0 °C(Predicted)
• Density: 1.072±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• pka: 9.21±0.10(Predicted)
• Appearance: White to off-white Solid
• InChI: InChI=1S/C19H27ClN2/c1-19(2)8-7-16(14-22-11-9-21-10-12-22)18(13-19)15-3-5-17(20)6-4-15/h3-6,21H,7-14H2,1-2H3
• InChIKey: YCNNHDUZLQPKJY-UHFFFAOYSA-N
• SMILES: N1(CC2CCC(C)(C)CC=2C2=CC=C(Cl)C=C2)CCNCC1

Description and Uses

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine is an intermediate of Venetoclax (ABT-199) which is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338