ML239 , 97% , 1378872-36-6

Synonym(s):
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide

CAS NO.：1378872-36-6

Empirical Formula: C13H10Cl3N3O2

Molecular Weight: 346.6

MDL number: MFCD23098913

EINECS: 604-604-1

PRODUCT Properties

• Density: 1.50±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMSO: soluble15mg/mL (clear solution)
• pka: 11.95±0.46(Predicted)
• form: powder
• color: white to beige
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 3 months.

Description and Uses

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 1.18 μM) over an isogenic control cell line (EC₅₀ = 27.6 μM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways. It is stable in saline and modestly stable in human plasma.

ML-239, is an inhibitor of breast cancer stem cells, with greater than 23 fold selectivity of inhibition in the cell line.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335-H400
• Precautionary statements: P273-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3