Embelin , 98% , 550-24-3

Synonym(s):
2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione;Apoptosis Activator III, Embelin - CAS 550-24-3 - Calbiochem;Embelic acid;Embelin, Embelia ribes, XIAP inhibitor, Embelin, 2,5-Dihydroxy-3-undecyl-1,4-benzoquinone;Emberine

CAS NO.：550-24-3

Empirical Formula: C17H26O4

Molecular Weight: 294.39

MDL number: MFCD00016369

EINECS: 208-979-8

Pack Size	Price	Stock	Quantity
50mg	RMB633.60	In Stock
100mg	RMB1013.60	In Stock
250mg	RMB1722.40	In Stock
1g	RMB4649.60	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	142-143°C
Boiling point:	356.15°C (rough estimate)
Density	1.131
refractive index	1.4230 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: >10 mg/mL
form	solid
pka	2.84±0.50(Predicted)
color	Dark orange
Sensitive	Light Sensitive
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP	5.024 (est)

Description and Uses

Embelin (550-24-3) inhibits?the lysine acetyl transferase PCAF?in vitro and in vivo?(in vitro?IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1? Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3?Possesses anti-inflammatory and analgesic activity?in vivo.4?Cell-permeable.

Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embelin also displays contraceptive and pro-apoptotic properties.