BD8450431
2,2-Dimethylpropanethioamide , 95% , 630-22-8
CAS NO.：630-22-8
Empirical Formula: C5H11NS
Molecular Weight: 117.21
MDL number: MFCD09742834
EINECS: 677-829-5
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB33.60 | In Stock |
|
| 1g | RMB84.80 | In Stock |
|
| 5g | RMB332.80 | In Stock |
|
| 10g | RMB559.20 | In Stock |
|
| 25g | RMB1128.80 | In Stock |
|
| 100g | RMB3386.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 117-119℃ (ethyl acetate hexane ) |
| Boiling point: | 162.1±23.0℃ (760 Torr) |
| Density | 0.978±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point: | 51.9±22.6℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Solid |
| pka | 13.33±0.29(Predicted) |
| color | White |
| Water Solubility | Soluble in water (10 g/L) (25°C). |
| InChI | InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7) |
| InChIKey | FJZJUSOFGBXHCV-UHFFFAOYSA-N |
| SMILES | C(N)(=S)C(C)(C)C |
Description and Uses
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312a-P330-P501a |
| HS Code | 2930909899 |