(R)-CPP , ≥98% , 126453-07-4
Synonym(s):
R-(−)-3-(2-Carboxypiperazin-4-yl)propanephosphonic acid
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB5040.00 | In Stock |
|
| 50mg | RMB20800.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 546.7±60.0 °C(Predicted) |
| Density | 1.408±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | Water: 100mM |
| form | White crystalline powder. |
| pka | 1.89±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble to 100 mM in water |
Description and Uses
(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
