Corosolicacid , Analysis of control products, 98% , 4547-24-4

Synonym(s):
Corosolic acid;2α-Hydroxyursolic acid;Glucosol;Colosolic acid;(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

CAS NO.：4547-24-4

Empirical Formula: C30H48O4

Molecular Weight: 472.7

MDL number: MFCD06794973

EINECS: 610-253-4

PRODUCT Properties

• Melting point: 243～245℃
• Boiling point: 573.3±50.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: methanol: soluble1mg/mL, clear, colorless
• pka: 4.67±0.70(Predicted)
• color: White
• LogP: 7.113 (est)

Description and Uses

Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC₅₀s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID₅₀ value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.

(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tumor activity

Safety

• WGK Germany: 3
• HS Code: 2918195000