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M7181058

Aminooxy-PEG3-acidHClsalt , 95% , 1807540-79-9

CAS NO.:1807540-79-9

Empirical Formula: C9 H19 N O6

Molecular Weight: 237.25

MDL number: MFCD26127821

Pack Size Price Stock Quantity
100mg RMB2688.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 415.9±40.0 °C(Predicted)
Density  1.181±0.06 g/cm3(Predicted)
pka 4.28±0.10(Predicted)
form  Oil
color  Colorless to light yellow

Description and Uses

Aminooxy-PEG3-acid HCl salt is a PEG linker containing an aminooxy group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

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