M7908747
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide , 98% , 202463-68-1
Synonym(s):
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide;AM 281
CAS NO.：202463-68-1
Empirical Formula: C21H19Cl2IN4O2
Molecular Weight: 557.21
MDL number: MFCD01861180
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1560.00 | In Stock |
|
| 10mg | RMB2240.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.70±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >6 mg/mL |
| form | solid |
| pka | 10.76±0.20(Predicted) |
| color | white |
Description and Uses
AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant . It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB1. It has also been used to study the membrane localization and cycling of CB1.
AM 281 acts as a potential CB1 selective receptor cannabinoid antagonist.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
