A0427456
Doxorubicinhydrochloride , 97% , 25316-40-9
Synonym(s):
DOX;Doxorubicin hydrochloride;Adriamycin;Adriamycin, HCl, 14-Hydroxydaunomycin, HCl;Hydroxydaunorubicin hydrochloride
CAS NO.：25316-40-9
Empirical Formula: C27H30ClNO11
Molecular Weight: 579.98
MDL number: MFCD00077757
EINECS: 246-818-3
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB127.20 | In Stock |
|
| 25mg | RMB399.20 | In Stock |
|
| 500mg | RMB495.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 216 °C (dec.)(lit.) |
| alpha | D20 +248±2° (c = 0.1 in methanol) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. |
| pka | pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain) |
| form | solid |
| color | orange to dark red |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in water. |
| λmax | 497nm(H2O)(lit.) |
| Merck | 14,3439 |
| BRN | 4229251 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
| InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
| CAS DataBase Reference | 25316-40-9(CAS DataBase Reference) |
| EPA Substance Registry System | Doxorubicin hydrochloride (25316-40-9) |
Description and Uses
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H340-H350-H360FD |
| Precautionary statements | P201-P202-P264-P270-P301+P312-P308+P313 |
| Hazard Codes | T,T+,Xi |
| Risk Statements | 45-22-40-26/27/28-36/38 |
| Safety Statements | 53-45-36/37/39-22-7/9 |
| RIDADR | UN2811 |
| WGK Germany | 3 |
| RTECS | QI9295900 |
| F | 10-21 |
| HazardClass | 6.1 |
| HS Code | 29419090 |
| Toxicity | LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970) |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
