ALLN , ≥95% , 110044-82-1
Synonym(s):
ALLN - CAS 110044-82-1 - Calbiochem;Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V;InSolution ALLN - CAS 110044-82-1 - Calbiochem;LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
CAS NO.：110044-82-1
Empirical Formula: C20H37N3O4
Molecular Weight: 383.53
MDL number: MFCD00065505
EINECS: 999-999-2
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB399.20 | In Stock |
|
| 10mg | RMB679.20 | In Stock |
|
| 25mg | RMB1191.20 | In Stock |
|
| 50mg | RMB2143.20 | In Stock |
|
| 100mg | RMB3815.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 182 °C |
| Boiling point: | 510.42°C (rough estimate) |
| Density | 1.1322 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| pka | 13.53±0.46(Predicted) |
| form | powder |
| color | white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers. |
| BRN | 7656053 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChI | 1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1 |
| InChIKey | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
| SMILES | [H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O |
Description and Uses
ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1Inhibits cell cycle progression at G1/Sand metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3Blocks AIF-mediated necroptosis.4Cell permeable.
Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.
Calpain Inhibitor I is used for western blotting methods.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 3-10 |
| HS Code | 29241900 |
| Storage Class | 11 - Combustible Solids |
