2-Amino-6-chloropurine riboside , 97% , 2004-07-1

CAS NO.：2004-07-1

Empirical Formula: C10H12ClN5O4

Molecular Weight: 301.69

MDL number: MFCD00005735

EINECS: 217-905-3

PRODUCT Properties

• Melting point: 165-167 °C (dec.)(lit.)
• Boiling point: 729.9±70.0 °C(Predicted)
• Density: 1.8359 (rough estimate)
• refractive index: -38 ° (C=0.1, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO, Methanol
• pka: 13.05±0.70(Predicted)
• form: Powder
• color: White to Off-white
• InChIKey: TXWHPSZYRUHEGT-ACJOCUEISA-N
• CAS DataBase Reference: 2004-07-1(CAS DataBase Reference)

Description and Uses

2-Amino-6-chloropurine riboside (1) is a a novel class of inhibitors of endogenous protein degradation for the preparation of a number of important purine nucleoside derivatives. For example, 6-thioguanosine 2 and 6-selenoguanosine 3 were prepared from a reaction of 1 and the corresponding sodium thiosulfate or potassium selenosulfate.1) 18O-labeled guanosine 4 was incubated from 1 with adenosine deaminase in (18O)-water.2) 2-Amino-6-ethoxypurine riboside 5 and 2-amino-N6-amino-N6-methyladenosine 6 were prepared by treatment of 1 with nucleophiles, sodium ethoxide and methylhydrazine, respectively.3,4) 2-Amino-N6-substituted purine analogues, as typified by 6, were reported as anti-malarial active compounds.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29349990