Aphidicolin , 98% , 38966-21-1

Synonym(s):
APC;Aphidicolin - CAS 38966-21-1 - Calbiochem;ICI 69653;InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem;NSC-234714

CAS NO.：38966-21-1

Empirical Formula: C20H34O4

Molecular Weight: 338.48

MDL number: MFCD00083214

EINECS: 609-602-3

PRODUCT Properties

• Melting point: 218-220°C
• alpha: D27 +12° (c = 1 in methanol)
• Boiling point: 394.61°C (rough estimate)
• Density: 1.0057 (rough estimate)
• vapor pressure: 0.55 hPa ( 20 °C)
• refractive index: 1.4434 (estimate)
• Flash point: 87℃
• storage temp.: 2-8°C
• solubility: ethanol: soluble1mg/mL (stable at least a week at 4°C.)
• form: White solid
• pka: 14.24±0.70(Predicted)
• color: colorless
• biological source: Nigrospora sphaerica
• optical activity: [α]27/D +12°, c = 1 in methanol(lit.)
• Water Solubility: Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°
• Merck: 13,734
• BRN: 4689958
• Stability: Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
• InChIKey: NOFOAYPPHIUXJR-APNQCZIXSA-N
• SMILES: O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO

Description and Uses

(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels. Aphidicolin can be used, at 3 μM, to arrest cells in G₁/S phase or to increase gene amplification frequency.

A DNA polymerase inhibitor. Blocks the cell cycle at the early S-phase

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P271-P280
• Safety Statements: 22-24
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• RTECS: PB9185000
• F: 10-21
• HS Code: 29419090
• Storage Class: 10 - Combustible liquids