Phorbol , 98% , 17673-25-5

CAS NO.：17673-25-5

Empirical Formula: C20H28O6

Molecular Weight: 364.43

MDL number: MFCD00065450

PRODUCT Properties

• Melting point: 162-163° and 233-234°; mp 249-250°
• alpha: D24 +102° (water); D20 +118° (c = 0.4 in dioxane)
• Boiling point: 415.62°C (rough estimate)
• Density: 1.4
• refractive index: 1.4450 (estimate)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• Water Solubility: Soluble in water
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: slightly soluble; PBS (pH 7.2): 1 mg/ml
• form: powder to crystal
• pka: 11.36±0.70(Predicted)
• color: White to Orange to Green
• InChIKey: QGVLYPPODPLXMB-UBTYZVCOSA-N
• SMILES: C1(=O)[C@]2(O)[C@]([H])([C@@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)C(C)(C)[C@@]4([H])[C@]3([H])C=C(CO)C2)C=C1C
• CAS DataBase Reference: 17673-25-5
• EPA Substance Registry System: Phorbol (17673-25-5)

Description and Uses

Phorbol is a diterpene originally isolated from croton oil. It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.

Phorbol is a plant-derived diterpene that exhibits various biological activities such as its role as tumor promoters through the activation of protein kinase C.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Hazard Codes: T+
• Risk Statements: 26/27/28-36/37/38
• Safety Statements: 26-27-36/37/39-45-28
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: GZ0600000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29062990
• Hazardous Substances Data: 17673-25-5(Hazardous Substances Data)