2-Amino-5-methylpyridine , 99% , 1603-41-4

Synonym(s):
2-Amino-5-picoline;6-Amino-3-picoline

CAS NO.：1603-41-4

Empirical Formula: C6H8N2

Molecular Weight: 108.14

MDL number: MFCD00006328

EINECS: 216-503-5

PRODUCT Properties

• Melting point: 76-77 °C(lit.)
• Boiling point: 227 °C(lit.)
• Density: 227
• vapor pressure: 3.706Pa at 25℃
• refractive index: 1,524-1,528
• Flash point: 118°C
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: 1000g/l
• form: Crystalline Powder, Crystals or Flakes
• pka: pK1: 7.22(+1) (25°C)
• color: White to light yellow
• Sensitive: Hygroscopic
• BRN: 107050
• InChIKey: CMBSSVKZOPZBKW-UHFFFAOYSA-N
• LogP: 1.08
• CAS DataBase Reference: 1603-41-4(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, 5-methyl-(1603-41-4)
• EPA Substance Registry System: 6-Amino-3-picoline (1603-41-4)

Description and Uses

2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301+H311-H315-H319-H335
• Precautionary statements: P280-P301+P310+P330-P302+P352+P312-P305+P351+P338
• Hazard Codes: T,Xi
• Risk Statements: 23/24/25-36/37/38-25
• Safety Statements: 26-36/37/39-45-37/39-28A
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: TJ5141000
• Hazard Note: Irritant
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29333999
• Toxicity: LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
• Limited Quantities: 100ml (liquid) or 0.5 Kg (solid)
• Excepted Quantities: Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)