3-Acetyl-2,5-dichlorothiophene , 98% , 36157-40-1

Synonym(s):
2,5-Dichloro-3-thienyl methyl ketone

CAS NO.：36157-40-1

Empirical Formula: C6H4Cl2OS

Molecular Weight: 195.07

MDL number: MFCD00014522

EINECS: 252-893-3

PRODUCT Properties

• Melting point: 37-40 °C (lit.)
• Boiling point: 120-122°C 4mm
• Density: 1.4514 (estimate)
• Flash point: >230 °F
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• form: solid
• color: White to Yellow to Orange
• BRN: 121288
• InChI: InChI=1S/C6H4Cl2OS/c1-3(9)4-2-5(7)10-6(4)8/h2H,1H3
• InChIKey: GYFDNIRENHZKGR-UHFFFAOYSA-N
• SMILES: C(=O)(C1C=C(Cl)SC=1Cl)C
• CAS DataBase Reference: 36157-40-1(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichloro-3-thienyl methyl ketone(36157-40-1)

Description and Uses

3-Acetyl-2,5-dichlorothiophene may be used in the following syntheses:

• substituted chalcones
• AL-4623A and AL-4862 (brinzolamide), inhibitors of topical carbonic anhydrase
• 2,5-dichlorothiophene-3-carboxylic acid, which is the starting reagent required for the synthesis of 2,5-dichloro-N-(substituted amino-carbonothioyl)thiophene-3-carboxamides and 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39-22-36/37
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29349990