Alvespimycin , 467214-20-6

CAS NO.：467214-20-6

Empirical Formula: C32H48N4O8

Molecular Weight: 616.75

MDL number: MFCD08457919

PRODUCT Properties

• Melting point: >270°C (dec.)
• Boiling point: 810.5±65.0 °C(Predicted)
• Density: 1.20
• storage temp.: Desiccate at -20°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 8.48±0.70(Predicted)
• color: Very Dark Purple
• InChIKey: KUFRQPKVAWMTJO-NTPQRYOENA-N
• SMILES: C1(NCCN(C)C)C(=O)C=C2NC(=O)C(=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=1C2=O)C |c:16,t:14,27,&1:18,21,29,31,33,37,r|

Description and Uses

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC₅₀ = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• HS Code: 29419090