Aciclovir , ≥99% , 59277-89-3

Synonym(s):
9-[(2-Hydroxyethoxy)methyl]guanine;Acycloguanosine;Acyclovir

CAS NO.：59277-89-3

Empirical Formula: C8H11N5O3

Molecular Weight: 225.2

MDL number: MFCD00057880

EINECS: 261-685-1

PRODUCT Properties

• Melting point: 256-257°C
• Boiling point: 366.71°C (rough estimate)
• Density: 1.3654 (rough estimate)
• refractive index: 1.8000 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: 0.7 mg/mL
• form: powder
• pka: pKa 2.27 (Uncertain);9.25 (Uncertain)
• color: white
• Water Solubility: Soluble in 1M HCl at 50mg/ml. Soluble in water at 0.7mg/ml. Also soluble in DMSO
• ε(extinction coefficient): 11.8 at 256nm at 1mM
• Merck: 14,146
• BCS Class: 4,3
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: MKUXAQIIEYXACX-UHFFFAOYSA-N
• LogP: -0.617 (est)
• CAS DataBase Reference: 59277-89-3(CAS DataBase Reference)
• IARC: 3 (Vol. 76) 2000

Description and Uses

As it is evident from the chemical structure, acyclovir looks like a nucleoside analog of guanosine in side chain of which, instead of the traditional cyclic sugar residue a 2-hydroxyethoxymethyl acyclic side chain is present. Acyclovir possesses antiviral activity with respect to types 1 and 2 of herpes simplex, shingles virus, Epstein–Barr virus, and cytomegalovirus.

Inhibits cytomegalovirus replication; induces apoptosis

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H320
• Precautionary statements: P264-P305+P351+P338+P337+P313
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-40-20/21/22
• Safety Statements: 22-24/25-36-26-23
• WGK Germany: 2
• RTECS: UP0791400
• HazardClass: IRRITANT
• HS Code: 29335990
• Hazardous Substances Data: 59277-89-3(Hazardous Substances Data)
• Toxicity: LD50 in mice (mg/kg): >10,000 orally; 1000 i.p. (Schaeffer)