AG-490 (Tyrphostin B42) , ≥98% , 133550-30-8
Synonym(s):
α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, ( E)- N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI;α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI;AG 490 - CAS 133550-30-8 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 20mg | RMB175.20 | In Stock |
|
| 50MG | RMB325.60 | In Stock |
|
| 250MG | RMB1359.20 | In Stock |
|
| 1G | RMB2639.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 215°C(lit.) |
| Boiling point: | 615.2±55.0 °C(Predicted) |
| Density | 1.337 |
| storage temp. | -20°C |
| solubility | ethanol: 5 mg/mL |
| form | solid |
| pka | 8.75±0.10(Predicted) |
| color | yellow |
| biological source | synthetic (organic) |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| InChIKey | TUCIOBMMDDOEMM-ZSOIEALJSA-N |
| SMILES | C(NCC1=CC=CC=C1)(=O)/C(/C#N)=C/C1=CC=C(O)C(O)=C1 |
Description and Uses
AG-490 (133550-30-8) is a potent inhibitor of the JAK2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock.3 AG-490 is a useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes.4
AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.
Safety
| Symbol(GHS) |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H301-H400 |
| Precautionary statements | P273-P301+P310 |
| Hazard Codes | Xi,N,T |
| Risk Statements | 36/37/38-50-25 |
| Safety Statements | 26-36-61-45 |
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
| WGK Germany | 1 |
| RTECS | UC6316197 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29269090 |
