SP600125 , ≥98% , 129-56-6

Synonym(s):
1,9-Pyrazoloanthrone;Anthrapyrazolone;JNK Inhibitor II - CAS 129-56-6 - Calbiochem;SAPK Inhibitor II, Anthra[1,9- cd]pyrazol-6(2 H)-one, 1,9-pyrazoloanthrone, SP600125

CAS NO.：129-56-6

Empirical Formula: C14H8N2O

Molecular Weight: 220.23

MDL number: MFCD00022289

EINECS: 204-955-6

PRODUCT Properties

• Melting point: 281~282℃
• Boiling point: 361.16°C (rough estimate)
• Density: 1.1702 (rough estimate)
• refractive index: 1.5910 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: insoluble
• form: Yellowish orange solid
• pka: 11.75±0.20(Predicted)
• color: yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
• InChI: InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
• InChIKey: ACPOUJIDANTYHO-UHFFFAOYSA-N
• SMILES: N1=C2C3=C(C=CC=C3)C(=O)C3=C2C(=CC=C3)N1
• CAS DataBase Reference: 129-56-6(CAS DataBase Reference)
• EPA Substance Registry System: Anthra[1,9-cd]pyrazol-6(2H)-one (129-56-6)

Description and Uses

SP-600125 (129-56-6) is a selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50‘s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Anti-inflammatory activity. SP-600125 inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.

SP 600125 is a Jun N-terminal kinase (JNK) inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: CB4585000
• TSCA: Yes
• HS Code: 29339900
• Toxicity: LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640