A0788612
Azathioprine , ≥98% , 446-86-6
Synonym(s):
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-[(1-Methyl-4-nitro-1H imidazol-5yl) sulfanyl]-7H-purine
CAS NO.：446-86-6
Empirical Formula: C9H7N7O2S
Molecular Weight: 277.26
MDL number: MFCD00069203
EINECS: 207-175-4
| Pack Size | Price | Stock | Quantity |
| 1G | RMB141.60 | In Stock |
|
| 5G | RMB410.40 | In Stock |
|
| 25G | RMB1945.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 243-244°C |
| Boiling point: | 521.0±60.0 °C(Predicted) |
| Density | 1.5379 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in Dichloromethane and dimethyl sulfoxide. |
| pka | 8.2(at 25℃) |
| form | Solid |
| color | Pale-yellow crystals from Me2CO (aq) |
| biological source | synthetic (organic) |
| Water Solubility | <0.1 g/100 mL at 23 ºC |
| Merck | 14,902 |
| BCS Class | 4 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | LMEKQMALGUDUQG-UHFFFAOYSA-N |
| CAS DataBase Reference | 446-86-6(CAS DataBase Reference) |
| IARC | 1 (Vol. 26, Sup 7, 100A) 2012 |
| EPA Substance Registry System | Azathioprine (446-86-6) |
Description and Uses
This immunosuppressive and antineoplastic drug is derived from 6-mercaptopurine. It caused occupational dermatitis in a pharmaceutical worker, reconditioner of old tablet packaging machines and in a production mechanic, working in packaging for a pharmaceutical company.
Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H335-H350-H361fd |
| Precautionary statements | P202-P261-P301+P312-P302+P352-P305+P351+P338-P308+P313 |
| Hazard Codes | Xi,T,Xn |
| Risk Statements | 45-22-36/37/38-20/21/22 |
| Safety Statements | 53-22-26-36/37-45-36 |
| WGK Germany | 3 |
| RTECS | UO8925000 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Hazardous Substances Data | 446-86-6(Hazardous Substances Data) |
| Toxicity | LD50 orl-rat: 535 mg/kg NIIRDN 6,3,82 |
