Acadesine , ≥98% , 2627-69-2
Synonym(s):
Acadesine;AMPK;PRKAB1;PRKAB2;PRKAG1
CAS NO.：2627-69-2
Empirical Formula: C9H14N4O5
Molecular Weight: 258.23
MDL number: MFCD00869751
EINECS: 220-097-5
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB240.80 | In Stock |
|
| 250MG | RMB812.80 | In Stock |
|
| 1G | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 214-215 °C |
| Boiling point: | 726.3±60.0 °C(Predicted) |
| Density | 2.06±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: >10 mg/mL |
| form | powder |
| pka | 13.27±0.70(Predicted) |
| color | tan |
| biological source | rabbit |
| Water Solubility | Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml |
| λmax | 265nm(NaOH)(lit.) |
| Merck | 14,16 |
| Specific Activity | 255-345nmol/min·mg |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| CAS DataBase Reference | 2627-69-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2) |
Description and Uses
AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315-H319-H360D |
| Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36-45-53 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29349990 |
