4-Amino-6-chloro-1,3-benzenedisulfonamide , >98.0% , 121-30-2

Synonym(s):
3-Chloroaniline-4,6-disulfonamide;4-Amino-6-chloro-1,3-benzenedisulfonamide;4-Amino-6-chlorobenzene-1,3-disulfonamide

CAS NO.：121-30-2

Empirical Formula: C6H8ClN3O4S2

Molecular Weight: 285.73

MDL number: MFCD00007933

EINECS: 204-463-1

PRODUCT Properties

• Melting point: 257-261 °C(lit.)
• Boiling point: 614.4±65.0 °C(Predicted)
• Density: 1.584 (estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 9.24±0.60(Predicted)
• form: Powder
• color: White to off-white
• Merck: 14,2076
• BRN: 1083877
• InChI: InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)
• InChIKey: IHJCXVZDYSXXFT-UHFFFAOYSA-N
• SMILES: C1(S(N)(=O)=O)=C(Cl)C=C(N)C(S(N)(=O)=O)=C1
• CAS DataBase Reference: 121-30-2(CAS DataBase Reference)
• EPA Substance Registry System: 1,3-Benzenedisulfonamide, 4-amino-6-chloro- (121-30-2)

Description and Uses

4-Amino-6-chlorobenzene-1,3-disulfonamide is obtained by treating the chloride with ammonia in tert-butanol and concentrating the solution by evaporation; the yield is 80 %. Condensation with formic acid gives 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, an important diuretic.

4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: T
• Risk Statements: 23/24-33-20/21
• Safety Statements: 28-36/37-36/37/39-26-22
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29350090