Capsanthin , Biochemicalreagent , 465-42-9

Synonym(s):
(3R,3′S,5′R)-3,3′-Dihydroxy-β,κ-caroten-6′-one

CAS NO.：465-42-9

Empirical Formula: C40H56O3

Molecular Weight: 584.87

MDL number: MFCD31726206

EINECS: 207-364-1

PRODUCT Properties

• Melting point: 177-178℃
• alpha: Cd +36° (chloroform)
• Boiling point: 581.82°C (rough estimate)
• Density: 1.012
• refractive index: 1.4960 (estimate)
• storage temp.: -20°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• form: Solid
• pka: 14.85±0.60(Predicted)
• color: Dark Red to Very Dark Brown
• optical activity: 〔α〕Cd +36 (CHCl3)
• λmax: λ: 467-471 nm Amax
• Merck: 14,1769
• Stability: Light Sensitive, Temperature Sensitive
• Cosmetics Ingredients Functions: COLORANT
• LogP: 9.467 (est)

Description and Uses

Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities. It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells. Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis. It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; ).

Capsanthin may be used as an analytical reference standard for the quantification of the analyte in red pepper powder, red pepper fruits, paprika and oleoresin using chromatography techniques.

Safety

• WGK Germany: 3
• HS Code: 2914.50.3000
• Hazardous Substances Data: 465-42-9(Hazardous Substances Data)