Acepromazine maleate , 98%(HPLC) , 3598-37-6

Synonym(s):
2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt;Acepromazine maleate salt;Acetopromazine maleate salt

CAS NO.：3598-37-6

Empirical Formula: C23H26N2O5S

Molecular Weight: 442.53

MDL number: MFCD00082473

EINECS: 222-748-9

PRODUCT Properties

• Melting point: 135-136°C
• storage temp.: room temp
• solubility: H2O: >10mg/mL
• pka: 9.3(at 25℃)
• form: powder
• color: yellow
• Water Solubility: H2O: >10mg/mL
• InChIKey: FQRHOOHLUYHMGG-BTJKTKAUSA-N
• SMILES: C12=CC(=CC=C1SC1C=CC=CC=1N2CCCN(C)C)C(=O)C.C(/C(=O)O)=C/C(=O)O

Description and Uses

Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine , and a dopamine receptor antagonist. It also binds to muscarinic receptors in rat brain (IC₅₀ = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (; IC₅₀ = 840 nM). Acepromazine inhibits morphine-induced vomiting in dogs. It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED₅₀s = 0.98, 3.1, and 17 mg/kg, respectively). Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.

Acepromazine maleate has been used:

• as a component of anesthesia cocktail to test its effects on behavioral changes in rats
• as a component of anesthesia cocktail to study its effects on lung resistance of rats
• as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H336
• Precautionary statements: P301+P310+P330
• target organs: Central nervous system
• Hazard Codes: Xn,N,T
• Risk Statements: 22-50/53-20/21/22-43-36/37/38-23/24/25
• Safety Statements: 60-61-36/37/39-26-22-45
• RIDADR: UN 3077
• WGK Germany: 2
• RTECS: 2664-15-5
• HS Code: 2934302300
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 3 Oral; STOT SE 3
• Toxicity: LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth)