Baicalein , 98% , 491-67-8

Synonym(s):
5,6,7-Trihydroxyflavone;Baicalein - CAS 491-67-8 - Calbiochem

CAS NO.：491-67-8

Empirical Formula: C15H10O5

Molecular Weight: 270.24

MDL number: MFCD00017459

EINECS: 000-000-0

PRODUCT Properties

• Melting point: 256-271 °C (lit.)
• Boiling point: 373.35°C (rough estimate)
• Density: 1.3280 (rough estimate)
• refractive index: 1.5000 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Yellow solid
• pka: 6.31±0.40(Predicted)
• color: Yellow or yellow-green
• Merck: 14,942
• BRN: 272683
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
• InChIKey: FXNFHKRTJBSTCS-UHFFFAOYSA-N
• LogP: 3.310 (est)
• CAS DataBase Reference: 491-67-8(CAS DataBase Reference)

Description and Uses

Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis.1?Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64 μM for 12-LO and 1.6 μM for 15-LO).2 Baicalein displays anti-inflammatory activity and inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (IC50=36 μM).3

An inhibitor of Ca2+ uptake, 5-LO, and 12-LO

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DJ3100898
• Hazard Note: Irritant
• HS Code: 29329990