BAPTA-AM , 95% , 126150-97-8
CAS NO.：126150-97-8
Empirical Formula: C34H40N2O18
Molecular Weight: 764.68
MDL number: MFCD00036696
EINECS: 634-129-4
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB263.20 | In Stock |
|
| 100MG | RMB799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 86-90°C |
| Boiling point: | 796.1±60.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in chloroform, dimethyl sulfoxide |
| form | powder |
| pka | 1.69±0.50(Predicted) |
| color | White |
| Appearance | white to beige solid |
| λmax | 287 nm |
| BRN | 7458534 |
| Stability: | Light Sensitive |
| Biological Applications | Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions |
| InChIKey | YJIYWYAMZFVECX-UHFFFAOYSA-N |
| SMILES | C(OC1=CC=CC=C1N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)COC1=CC=CC=C1N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O |
| CAS DataBase Reference | 126150-97-8(CAS DataBase Reference) |
Description and Uses
BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge.1,2 Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases. Pretreatment of cells with BAPTA-AM inhibits thapsigargin-induced responses.3
BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 8-10-21 |
| HS Code | 2921490090 |
