6-Biopterin , ≥97% , 22150-76-1

Synonym(s):
(1’R,2’S)-Biopterin;L-erythro-6-(1,2-Dihydroxypropyl)pterin;2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine

CAS NO.：22150-76-1

Empirical Formula: C9H11N5O3

Molecular Weight: 237.22

MDL number: MFCD00036787

EINECS: 244-807-8

PRODUCT Properties

• Melting point: >210°C dec.
• alpha: D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH)
• Boiling point: 379.74°C (rough estimate)
• Density: 1.3472 (rough estimate)
• refractive index: 1.7610 (estimate)
• storage temp.: 2-8°C
• solubility: Aqueous Acid (Slightly, Heated, Sonicated)
• form: White to pale yellow powder.
• pka: 13.18±0.20(Predicted)
• color: White to Light Yellow
• Merck: 13,1229
• BRN: 87860
• Stability: Hygroscopic
• InChI: InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1
• InChIKey: LHQIJBMDNUYRAM-DZSWIPIPSA-N
• SMILES: N1C2C(=NC([C@@H](O)[C@@H](O)C)=CN=2)C(=O)N=C1N
• CAS DataBase Reference: 22150-76-1(CAS DataBase Reference)

Description and Uses

6-Biopterin (L-Biopterin) is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.

L-Biopterin is a pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UO3506000
• F: 10-23
• HS Code: 29339900
• Toxicity: sln-par-dmg 10 mg/L MUREAV 128,147,84