(S)-1-Boc-3-hydroxypiperidine , 97% , 143900-44-1
Synonym(s):
(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate
| Pack Size | Price | Stock | Quantity |
| 1G | RMB23.20 | In Stock |
|
| 5G | RMB31.20 | In Stock |
|
| 25g | RMB3079.20 | In Stock |
|
| 100g | RMB7999.20 | In Stock |
|
| 500g | RMB23999.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 34-40 °C |
| Boiling point: | 292.3±33.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Flash point: | 110 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 14.74±0.20(Predicted) |
| form | Powder or Crystalline Powder |
| color | White to tan |
| optical activity | [α]22/D +10.0°, c = 1 in chloroform |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
| InChIKey | UIJXHKXIOCDSEB-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1 |
| CAS DataBase Reference | 143900-44-1(CAS DataBase Reference) |
Description and Uses
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| HS Code | 29339900 |
