Benidipine HCl , ≥98%(HPLC) , 91599-74-5

Synonym(s):
(4R)-rel-3,5-Pyridinedicarboxylic acid;1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-;3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester;hydrochloride (1:1);KW-3049

CAS NO.：91599-74-5

Empirical Formula: C28H31N3O6

Molecular Weight: 505.56

MDL number: MFCD00906929

EINECS: 663-500-3

PRODUCT Properties

• Melting point: 199-201°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO: ≥20mg/mL
• pka: 7.34(at 25℃)
• form: powder
• color: yellow
• InChIKey: DGVVISBYHUXFIU-UHFFFAOYSA-N
• SMILES: C(C1=C(NC(=C([C@H]1C1C=CC=C(C=1)N(=O)=O)C(=O)OC)C)C)(=O)O[C@@H]1CCCN(C1)CC1C=CC=CC=1.Cl
• CAS DataBase Reference: 91599-74-5(CAS DataBase Reference)

Description and Uses

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

A dihydropyridine calcium channel blocker. Antihypertensive.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: US7975657
• HS Code: 2933.99.5300
• HazardClass: 6.1
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 3 Oral
• Toxicity: LD50 orally in male mice: 218 mg/kg (Muto, 1988)
• Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)