A1567050
PBIT , ≥98%(HPLC) , 2514-30-9
Synonym(s):
2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one;2-p-Tolyl-1,2-benzisothiazolin-3-one
CAS NO.：2514-30-9
Empirical Formula: C14H11NOS
Molecular Weight: 241.31
MDL number: MFCD05856231
EINECS: 604-604-1
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB503.20 | In Stock |
|
| 10mg | RMB896.00 | In Stock |
|
| 25mg | RMB2015.20 | In Stock |
|
| 50mg | RMB3631.20 | In Stock |
|
| 100mg | RMB6535.20 | In Stock |
|
| 250mg | RMB11439.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 136.7-137.1 °C(Solv: benzene (71-43-2); hexane (110-54-3)) |
| Boiling point: | 418.2±38.0 °C(Predicted) |
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear (warmed) |
| pka | -0.03±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Description and Uses
Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 μM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It does not significantly affect the activity of UTX and JMJD3 demethylases. It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319-H315-H335-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | 3 |
