A1706712
Bufalin , 98%(HPLC) , 465-21-4
Synonym(s):
3β,14-Dihydroxy-5β,20(22)-bufadienolide;5β, 20(22)-Bufadienolide-3β, 14-diol;5β,20(22)-Bufadienolide-3β,14-diol;Bufalin - CAS 465-21-4 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB559.20 | In Stock |
|
| 50mg | RMB1999.20 | In Stock |
|
| 250mg | RMB7039.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 242-243° |
| alpha | D -20° |
| Boiling point: | 556.6±50.0 °C(Predicted) |
| Density | 1.226±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM) Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM) |
| form | White to off-white solid |
| pka | 15.01±0.70(Predicted) |
| color | White to off-white |
| InChIKey | QEEBRPGZBVVINN-ONGIWDLKSA-N |
| SMILES | O[C@]12CC[C@H](C3=COC(C=C3)=O)[C@]1(CC[C@]1([H])[C@]3(CC[C@@H](C[C@@]3([H])CC[C@@]21[H])O)C)C |
Description and Uses
Bufalin has been used:
- to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)
- as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes
- to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P301+P310+P330 |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | EI2962500 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29322090 |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
