Btk inhibitor 1 R enantiomer , 98% , 1022150-12-4

CAS NO.：1022150-12-4

Empirical Formula: C22H22N6O

Molecular Weight: 386.45

MDL number: MFCD20482137

EINECS: 200-001-8

PRODUCT Properties

• Melting point: 133-136oC
• Boiling point: 626.3±55.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 9.00±0.10(Predicted)
• form: Solid
• color: White to Pale Yellow
• optical activity: -9.6828°(C=0.5249g/100ml MEOH)
• InChIKey: GPSQYTDPBDNDGI-MRXNPFEDSA-N
• SMILES: C1=NC(N)=C2C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN([C@@H]3CCCNC3)C2=N1

Description and Uses

IBT6A is a Btk kinase inhibitor. This compound is a precurser for the manufacture of ibrutinib.

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton''s tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313