JZL184

Synonym(s):
4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184;MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem

CAS NO.：

Empirical Formula: C27H24N2O9

Molecular Weight: 520.49

MDL number:

PRODUCT Properties

• Melting point: 116-120°C
• Boiling point: 706.4±60.0 °C(Predicted)
• Density: 1.467±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 25 mg/ml).
• form: White to off-white solid
• pka: 13.32±0.29(Predicted)
• color: light yellow to yellow-green
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
• InChIKey: SEGYOKHGGFKMCX-UHFFFAOYSA-N
• SMILES: N1(C(OC2=CC=C([N+]([O-])=O)C=C2)=O)CCC(C(C2=CC=C3OCOC3=C2)(C2=CC=C3OCOC3=C2)O)CC1
• CAS DataBase Reference: 1101854-58-3

Description and Uses

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC₅₀ values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB₁) agonists.

JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• RIDADR: UN 2811 6.1 / PGIII
• HS Code: 29349990