BEZ235 , ≥99% , 915019-65-7
CAS NO.：915019-65-7
Empirical Formula: C30H23N5O
Molecular Weight: 469.55
MDL number: MFCD10565944
EINECS: 1312995-182-4
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB239.20 | In Stock |
|
| 100MG | RMB719.20 | In Stock |
|
| 1G | RMB2561.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 288-289°C |
| Boiling point: | 701.0±70.0 °C(Predicted) |
| Density | 1.299 |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C). |
| pka | 6.41±0.20(Predicted) |
| form | White powder. |
| color | White or off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 |
| InChIKey | JOGKUKXHTYWRGZ-UHFFFAOYSA-N |
| SMILES | O=C1N(C2C=NC3=CC=C(C4C=NC5C=CC=CC=5C=4)C=C3C=2N1C1C=CC(C(C)(C)C#N)=CC=1)C |
| CAS DataBase Reference | 915019-65-7 |
Description and Uses
NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1?It inhibits VEGF-induced proliferation and angiogenesis.2?Reverses lapatinib resistance.3?It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4?NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5?The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6?Active in vivo.
Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
