GDC-0941 , ≥98% , 957054-30-7

CAS NO.：957054-30-7

Empirical Formula: C23H27N7O3S2

Molecular Weight: 513.64

MDL number: MFCD11616196

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: >200oC (dec.)
• Density: 1.53±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO (>25 mg/ml)
• pka: 12.22±0.40(Predicted)
• form: White powder solid.
• color: White/off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: LHNIIDJUOCFXAP-UHFFFAOYSA-N
• SMILES: C1(C2=CC=CC3=C2C=NN3)=NC(N2CCOCC2)=C2SC(CN3CCN(S(C)(=O)=O)CC3)=CC2=N1

Description and Uses

GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• HS Code: 29350090