Cytosine β-D-arabinofuranoside , 98% , 147-94-4
Synonym(s):
Cytarabine;Arabinosylcytosine;Ara-C;Cytosine arabinoside;(β-D -Arabinofuranosyl)cytosine
CAS NO.：147-94-4
Empirical Formula: C9H13N3O5
Molecular Weight: 243.22
MDL number: MFCD00066487
EINECS: 205-705-9
| Pack Size | Price | Stock | Quantity |
| 1G | RMB34.40 | In Stock |
|
| 5G | RMB96.00 | In Stock |
|
| 25G | RMB332.80 | In Stock |
|
| 100G | RMB1212.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 214 °C |
| alpha | D24 +153° (c = 0.5 in water) |
| Boiling point: | 386.09°C (rough estimate) |
| Density | 1.3686 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | crystalline |
| pka | pKa 4.3 (Uncertain) |
| color | Prisms from EtOH (aq) |
| Water Solubility | almost transparency |
| λmax | 272nm(H2O)(lit.) |
| Merck | 14,2784 |
| BRN | 89175 |
| Stability: | Stable for 1 year as supplied from date of purchase. Solutions in DMSO or water may be stored at -20°C for up to 1 month. |
| InChIKey | UHDGCWIWMRVCDJ-STUHELBRSA-N |
| LogP | -1.808 (est) |
| CAS DataBase Reference | 147-94-4(CAS DataBase Reference) |
| EPA Substance Registry System | Cytarabine (147-94-4) |
Description and Uses
Cytarabine (147-94-4) is a nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6
Cytarabine USP (Cytosar)is used to treat Acute granulocytic leukemia (adults); acute lymphocytic leukemia (children); Hodgkin’s disease
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H317-H361fd |
| Precautionary statements | P202-P261-P272-P280-P302+P352-P308+P313 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 43-63-36/37/38-20/21/22 |
| Safety Statements | 36/37-37/39-36-26 |
| WGK Germany | 3 |
| RTECS | HA5425000 |
| F | 10-23 |
| HS Code | 29349990 |
| Hazardous Substances Data | 147-94-4(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: > 5gm/kg |
