A2461012
Clozapine , ≥98% , 5786-21-0
Synonym(s):
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine;Clozapine
CAS NO.：5786-21-0
Empirical Formula: C18H19ClN4
Molecular Weight: 326.82
MDL number: MFCD00153785
EINECS: 227-313-7
| Pack Size | Price | Stock | Quantity |
| 1G | RMB28.00 | In Stock |
|
| 5G | RMB38.40 | In Stock |
|
| 25G | RMB140.80 | In Stock |
|
| 100G | RMB443.20 | In Stock |
|
| 500g | RMB1759.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 182-185°C |
| Boiling point: | 482.71°C (rough estimate) |
| Density | 1.1327 (rough estimate) |
| refractive index | 1.6110 (estimate) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 1 mg/mL |
| pka | 3.70, 7.60(at 25℃) |
| form | powder |
| color | pale yellow |
| Merck | 14,2423 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| InChIKey | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
| SMILES | N1=C(N2CCN(C)CC2)C2=CC=CC=C2NC2=CC=C(Cl)C=C12 |
| CAS DataBase Reference | 5786-21-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Clozapine(5786-21-0) |
Description and Uses
Clozapine (5786-21-0) is a dopamine D4?and D2?receptor antagonist. High affinity for the cloned rat dopamine D4?receptor (Ki?< 20 nM).1?Atypical neuroleptic agent.2?Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4
Clozapine is a neuroleptic, which expresses antipsychotic and sedative action. It does not cause general depression and extrapyramidal disorders. It is used for severe and chronic forms of schizophrenia, maniacal conditions, manic-depressive psychosis, psychomotor excitement, and various other psychotic conditions.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H341-H361 |
| Precautionary statements | P201-P202-P264-P270-P280-P301+P310 |
| Hazard Codes | Xn,Xi,T,F |
| Risk Statements | 22-36/37/38-68-63-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36/37-45-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | HP1750000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29339900 |
| Hazardous Substances Data | 5786-21-0(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt) |
