Olanzapine , ≥99% , 132539-06-1

Synonym(s):
2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine;LY-170053;Olanzapine

CAS NO.：132539-06-1

Empirical Formula: C17H20N4S

Molecular Weight: 312.43

MDL number: MFCD00866702

EINECS: 603-618-4

PRODUCT Properties

• Melting point: 195°C
• Boiling point: 476.0±55.0 °C(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)
• Flash point: 2℃
• storage temp.: 2-8°C
• solubility: DMSO: >15mg/mL
• form: powder
• pka: 7.78±0.20(Predicted)
• color: yellow
• Merck: 14,6822
• BRN: 7655141
• BCS Class: 2
• InChI: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
• InChIKey: KVWDHTXUZHCGIO-UHFFFAOYSA-N
• SMILES: N1C2=CC=CC=C2N=C(N2CCN(C)CC2)C2C=C(C)SC1=2
• CAS DataBase Reference: 132539-06-1(CAS DataBase Reference)
• NIST Chemistry Reference: Olanzapine(132539-06-1)

Description and Uses

O lanzapine is classed as an atypical antipsychotic and is considered a firstline agent in the management of newly diagnosed psychosis. It has a similar mechanism of action to classical antipsychotics but with a lower incidence of adverse events. O lanzapine rarely produces hypotension and has less potential for QT prolongation. It is used in the management of delirium in ICU.

intermediate for Imidacloprid, Indobufen, Nitroguanidine, Nalorphine, Tazarotene, Trovafloxacin

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
• Hazard Codes: Xi,Xn,F
• Risk Statements: 36/38-36-20/21/22-11
• Safety Statements: 26-36/37-16
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: XJ9007750
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29349990
• Hazardous Substances Data: 132539-06-1(Hazardous Substances Data)
• Toxicity: human,TDLo,oral,16560ug/kg/12 (16.56mg/kg),Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.