Cortisone acetate , ≥98%(HPLC) , 50-04-4
Synonym(s):
17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate;21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione;4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate;Cortisone 21-acetate;Cortisone acetate
CAS NO.：50-04-4
Empirical Formula: C23H30O6
Molecular Weight: 402.48
MDL number: MFCD00003609
EINECS: 200-006-5
| Pack Size | Price | Stock | Quantity |
| 1G | RMB55.20 | In Stock |
|
| 5G | RMB103.20 | In Stock |
|
| 25G | RMB386.40 | In Stock |
|
| 100G | RMB1328.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 237-240 °C(lit.) |
| alpha | D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane) |
| Boiling point: | 577.3±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| refractive index | 212 ° (C=1, MeOH) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol. |
| form | Solid |
| pka | 12.32±0.60(Predicted) |
| color | White to Off-White |
| Water Solubility | 19mg/L(25 ºC) |
| Merck | 14,2539 |
| BRN | 2067543 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-04-4(CAS DataBase Reference) |
| EPA Substance Registry System | Cortisone acetate (50-04-4) |
Description and Uses
Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.
Cortisone Acetate (Hydrocortisone Acetate EP Impurity D) is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H373-H361 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| Safety Statements | 22-36/37-24/25 |
| WGK Germany | 3 |
| RTECS | GM9140000 |
| HS Code | 32041200 |
