RU58841 , 99% , 154992-24-2

CAS NO.：154992-24-2

Empirical Formula: C17H18F3N3O3

Molecular Weight: 369.34

MDL number: MFCD00925776

EINECS: 1592732-453-0

PRODUCT Properties

• Boiling point: 493.6±55.0 °C(Predicted)
• Density: 1.39
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
• form: Powder
• pka: 15.09±0.10(Predicted)
• color: White to off-white
• InChI: InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
• InChIKey: ARBYGDBJECGMGA-UHFFFAOYSA-N
• SMILES: C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F

Description and Uses

RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.

Avoid hair loss: RU58841 is a non-steroidal antiandrogenic medication that was initially developed in the 1980s as a topical treatment remedy for acne and male pattern baldness – androgenetic alopecia.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314-H290
• Precautionary statements: P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405