2,6-Difluorophenylboronic acid , 98% , 162101-25-9

CAS NO.：162101-25-9

Empirical Formula: C6H5BF2O2

Molecular Weight: 157.91

MDL number: MFCD01318987

EINECS: 627-874-1

PRODUCT Properties

• Melting point: 147-149 °C (lit.)
• Boiling point: 260.1±50.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Soluble in methanol.
• form: solid
• pka: 8.12±0.58(Predicted)
• color: White to Almost white
• BRN: 8545931
• InChI: InChI=1S/C6H5BF2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H
• InChIKey: DBZAICSEFBVFHL-UHFFFAOYSA-N
• SMILES: B(C1=C(F)C=CC=C1F)(O)O
• CAS DataBase Reference: 162101-25-9(CAS DataBase Reference)

Description and Uses

2,6-Difluorophenylboronic acid can be used:

• As a substrate in the model reaction of Suzuki–Miyaura coupling with?4-chloro-3-methylanisole.
• To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
• To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29163990